Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors
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13-desmethyl rhodopsin and 13-desmethyl isorhodopsin: visual pigment analogues.
The preparation and properties of three geometric isomers of 13-desmethyl retinal (13-dmr) are described. They are analogous to the all-trans, 11-cis, and 9-cis isomers of retinal since two of the cis isomers combine with cattle opsin to form pigments which are spectrally indistinguishable from rhodopsin and isorhodopsin and the all-trans isomer is unreactive.The pigment which resembles rhodops...
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متن کاملIntracellular domains of NR2 alter calcium-dependent inactivation of N-methyl-D-aspartate receptors.
At central excitatory synapses, the transient elevation of intracellular calcium reduces N-methyl-D-aspartate (NMDA) receptor activity. Such 'calcium-dependent inactivation' is mediated by interactions of calcium/calmodulin and alpha-actinin with the C terminus of NMDA receptor 1 (NR1) subunit. However, inactivation is also NR2-subunit specific, because it occurs in NR2A- but not NR2C-containin...
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ژورنال
عنوان ژورنال: Toxins
سال: 2020
ISSN: 2072-6651
DOI: 10.3390/toxins12120751